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Benefits, Side Effects, and How Jardiance Works

Wednesday 13 December 2023
4 minute(s) read

Table of Contents

I. What Is Jardiance?

II. How Does Jardiance Work?

III. Benefits of Managing Type 2 Diabetes with Jardiance

IV. Potential Side Effects

V. Jardiance During Pregnancy

VI. Jardiance Dosage

VII. Important Drug Interactions

VIII. Conclusion

Diabetes management often requires a combination of lifestyle changes and proper medication. However, with the plethora of diabetes drugs on the market, it can be hard to decide the right one for you.

In this article, we’ll demystify one of these medications: Jardiance (empagliflozin), a promising drug for treating type 2 diabetes. We’ll discuss what it is, how it works, potential side effects, recommended dosage, and its interactions with other medications.

What Is Jardiance?

an older man looking at the prescription label

Jardiance was manufactured by Boehringer Ingelheim and Eli Lilly and Company [1] and was approved by the FDA in 2014 to:

  • Decrease the risk of cardiovascular death in adults with cardiovascular disease and/or type 2 diabetes mellitus
  • Improve glycemic control in adults with type 2 diabetes (when combined with diet and exercise) [2]

Currently, only brand-named Jardiance is available in the US. However, due to Canada’s different patent laws, generic Jardiance (empagliflozin) is available to purchase through an online Canadian pharmacy like Canada Drug Warehouse.

How Does Jardiance Work?

The active ingredient in Jardiance is empagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor. [2]

Let’s break that down into simple terms.

Jardiance works by inhibiting the SGLT2 proteins in the kidneys. These proteins are responsible for reabsorbing glucose back into the bloodstream instead of letting it pass into the urine for excretion. Therefore, by blocking SGLT2, Jardiance allows excess glucose to be flushed out of the body through urine, which reduces blood sugar levels. [2]

This unique approach helps control blood glucose and offers additional benefits like weight loss and reduced blood pressure. However, it’s important to note that optimal results with Jardiance are only achieved alongside a healthy diet and exercise. [2]

Benefits of Managing Type 2 Diabetes

an older couple going on a hike

Managing type 2 diabetes can be frustrating and often requires a good balance of medication and lifestyle changes. But, it’s important to recognize that effective blood sugar management is key to leading a long and healthy life. The long-term complications of untreated diabetes manifest over many years, and most are due to consistently high blood sugar. These complications can include heart disease, nerve damage, vision loss, and even death. [3]

Keeping your blood sugar levels in check decreases your risk of eye disease, nerve issues, and kidney problems by 40%. [4]

While medications like Jardiance help lower your blood sugar levels, you must do your part by making healthy lifestyle changes. This includes eating healthier meals, regular physical activity, managing stress effectively, and monitoring your blood sugar levels regularly. [5]

Potential Side Effects

Jardiance may cause side effects like any medication, although not everyone experiences them.

Common side effects may include:

  • Urinary tract infection (UTI)
  • Female genital mycotic infection [2]

Less common side effects may include:

  • Ketoacidosis
  • Volume depletion
  • Hypoglycemia
  • Fournier’s Gangrene
  • Hypersensitivity reactions [2]

If you experience any of the above, contact your doctor immediately. If you have any questions about side effects, contact your physician.

It's crucial to promptly report any concerning side effects to healthcare providers for timely evaluation and management.

Jardiance During Pregnancy

a pregnant mother and her daughter

Jardiance is not recommended:

  • During the second and third trimester of pregnancy
  • While breastfeeding [2]

While there isn’t sufficient research showing a correlation between Jardiance usage and miscarriage, the research that does exist shows that Jardiance is able to pass through the placenta and reach the fetus. For this reason, the FDA does not recommend Jardiance usage during late pregnancy and breastfeeding. [2]

However, poorly controlled diabetes in the mother poses risks to the fetus. [2] Because of this, it’s important to consult your doctor about Jardiance usage during pregnancy and while breastfeeding. 

Jardiance Dosage

The recommended dosage of Jardiance can vary depending on an individual's specific health needs and medical history.

Typically, the starting dose is 10 mg, taken orally once a day, with or without food. The dosage can be increased to 25 mg once daily if additional glycemic control is needed. [2]

It's vital to strictly adhere to your healthcare provider's prescribed dosage and not modify it without medical consultation.

Important Drug Interactions

Before starting Jardiance, inform your healthcare provider about all medications, supplements, or herbal products you are taking. Certain medications may lead to adverse effects when taken with Jardiance.

Medications that lower blood sugar levels (e.g., insulin) can increase the risk of hypoglycemia (low blood sugar) when combined with Jardiance. Your doctor will work with you to adjust your insulin dose to prevent this side effect. [2]

Additionally, medications that cause dehydration or have a diuretic effect may intensify Jardiance's diuretic effect and raise the risk of dehydration. Your doctor will work with you to monitor your blood volume during therapy. [2]


Jardiance has emerged as a valuable ally in managing type 2 diabetes.

However, as with any medication, it's essential to be aware of potential side effects and drug interactions. Patients should communicate openly with their healthcare providers and promptly report concerns to ensure optimal diabetes management.

With the right knowledge, treatment, and support team, you can start managing type 2 diabetes and begin the road to wellness today.

The content in this article is intended for informational purposes only. This website does not provide medical advice. In all circumstances, you should always seek the advice of your physician and/or other qualified health professionals(s) for drug, medical condition, or treatment advice. The content provided on this website is not a substitute for professional medical advice, diagnosis, or treatment.