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What is Rybelsus?

Rybelsus is an oral medication used to treat type 2 diabetes. It contains semaglutide, which is a GLP-1 receptor agonist. Essentially, Rybelsus works by increasing the body's insulin release in order to decrease blood sugar levels. Rybelsus also slows down gastric emptying, which is the process of moving food through the stomach. This further helps with lowering overall blood sugar levels. [1]

One study found that Rybelsus lowers blood sugar more effectively than a placebo. In this study, researchers found that Rybelsus helped lower hemoglobin A1c levels by 1.2 to 1.4 percent. Rybelsus is only approved for treating type 2 diabetes. The FDA does not approve Rybelsus for treating type 1 diabetes or for weight loss.


  1. [1]  Andreas Andersen, Filip Krag Knop, and Tina Vilsbøll A Pharmacological and Clinical Overview of Oral Semaglutide for the Treatment of Type 2 Diabetes

Rybelsus is typically taken once a day, at least 30 minutes before your first meal. This medication should not be taken with food or any beverages. However, you may take it with plain water (no more than 4 ounces).

If you take other medications, make sure to take Rybelsus at least 30 minutes before your other pills. Leaving time between medications allows for Rybelsus to work properly. Taking Rybelsus at the same time each day can help you remember your dose. Talk to your healthcare provider for more details on how to take Rybelsus.


Rybelsus comes with a boxed warning from the FDA because it has been shown to cause tumors in the thyroid gland in animal studies. If you or someone in your family has a history of medullary thyroid carcinoma (MTC), Rybelsus may not be safe for you. Similarly, your doctor may tell you to avoid Rybelsus if you have endocrine neoplasia syndrome type 2. 

Other conditions that may increase the risk of complications with Rybelsus include pancreatitis, chronic kidney failure, and diabetic retinopathy. Additionally, your doctor may recommend avoiding Rybelsus if you are pregnant or breastfeeding, as it isn't known whether this medication is safe to take for current or expecting mothers.

Side Effects

Although Rybelsus does not cause side effects in everyone, it is important to know the potential side effects of this drug before starting treatment. The most common mild side effects of Rybelsus are weight loss, constipation, diarrhea, and belly pain. Nausea, vomiting, and a decreased appetite are also common. These milder side effects tend to go away on their own. However, we advise you to seek medical attention if your side effects worsen or last longer than a few weeks.

More severe side effects of Rybelsus include:

  • Pancreatitis
  • Diabetic retinopathy
  • Sudden kidney issues
  • Low blood sugar

Call your doctor right away if you experience any signs of the severe side effects listed above. Also, seek medical attention right away if you have an allergic reaction to semaglutide.


How does Rybelsus work for weight loss?

Weight loss is a known side effect of Rybelsus. However, Rybelsus is not currently indicated for weight loss. Rybelsus is only approved to help lower blood sugar levels in those with type 2 diabetes.

Why is Rybelsus so expensive?

Rybelsus is an expensive diabetes medication because it is not available in a generic form yet. Rybelsus is also one of the leading brand-name drugs that utilize semaglutide to help those with diabetes manage their blood sugar.

To save on Rybelsus, use an online Canadian pharmacy such as Canada Drug Warehouse to fill your order. At Canada Drug Warehouse, we offer brand-name drugs and fast, discreet shipping at significant discounts.

What is Rybelsus used for?

Rybelsus is used for controlling blood sugar in adults with type 2 diabetes. Rybelsus contains the active ingredient semaglutide, which works by helping your body produce more insulin to convert food into energy.

How long does it take for Rybelsus to start working?

When you use Rybelsus as directed, you will typically feel the benefits of this drug after 30 days. It takes Rybelsus around one month of consistent use to reach a steady level in your system.

What happens if you take Rybelsus with food?

It is recommended that you take Rybelsus without food so that it is properly absorbed into your body. Taking Rybelsus with food may cause several complications. For example, it may prevent Rybelsus from working to its full effect, leading to blood sugar spikes and any accompanying symptoms.

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Linda C

January 9, 2023

I love Canada Drug Warehouse. They are super efficient and I like that they call me when one of my medications is about to expire. They have saved me thousands of dollars. This is a great company!!!!!!

James D

October 14, 2022

My prescription was received in 14 business days from the date of payment. The meds arrived in individual sealed pill packs. This was my first order and very pleased with their prompt and courteous service.

John H

October 1, 2022

Very informed and efficient agent taking order. Delivery when promised. Outstanding service.

Robert C

September 9, 2022

Meds received in a timely manner.


September 8, 2022

This is an absolutely reliable source of prescription meds and I have saved more than $5,000 in one year by ordering from them. Highly recommend.

Donald K

September 7, 2022

I have only good things to say about Canada Drug Warehouse. Please keep up the good work.

A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

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