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IMPORTANT NOTE: A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.
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What is Prempro?

Prempro is a medication used to treat the symptoms of menopause such as hot flashes, vaginal changes and to prevent osteoporosis in menopausal women. Prempro contains a combination of conjugated estrogens and medroxyprogesterone. Estrogen is a hormone produced by the ovaries which are necessary for many body processes while medroxyprogesterone is a hormone which is important for regulating ovulation and menstruation.  

Always read the patient information and instructions carefully before using this medication.

  • Prempro is taken orally with or without food and is typically taken once daily. To prevent upset stomach it may be taken with food or immediately after eating.
  • Your Prempro dosage is based on your medical condition and your response to treatment. You should not increase or change your dosage without speaking to a doctor.
  • Prempro is most effective when it is taken regularly. Try to take Prempro at the same time each day.
  • Tell your doctor if your condition does not improve or worsens.


Make sure to tell your doctor and pharmacist:

  • If you have any drug allergies.
  • Which other prescription and non-prescription medications you currently take.
  • Your medical history especially of vaginal bleeding of an unknown cause, cancer, stroke, heart disease, liver disease, kidney disease, angioedema, blood clotting disorders, high blood pressure, diabetes, high blood cholesterol, obesity, lupus, underactive thyroid, mineral imbalance, hypoparathyroidism, uterus problems, gallbladder disease, asthma, seizures, migraines, porphyria or mental or mood disorders.
  • Your personal or family history of breast lumps, cancer or blood clots.
  • If you have just had or will be having surgery or if you will be confined to a bed or chair for a long time such as during a long plane flight. These conditions may increase your chance of getting blood clots and you may need to temporarily stop taking this medication or take special precautions.
  • If you are pregnant, planning on pregnancy or breast feeding.

Also be aware that:

  • You should not smoke or drink tobacco while taking this medication. Combining estrogen and smoking can increase your risk of stroke, blood clots, high blood pressure and heart attack, especially in women older than 35.
  • Prempro may cause blotchy, dark areas on your face and skin. Sunlight can worsen this effect. You should limit your time in the sun and wear protective clothing and sunscreen. Avoid using tanning booths or sunlamps.
  • If you are nearsighted or wear contact lenses, you may develop vision problems. Talk to your eye doctor if these problems persist.
  • Prempro must not be used during pregnancy. This medication may reduce the quality and quantity of your breast milk.

Side Effects of Prempro

Common Prempro side effects may include but are not limited to:

  • Nausea, gas or stomach pain.
  • Headache, back pain or breast pain.
  • Depression.
  • Weakness.
  • Itching or thinning scalp hair.
  • Vaginal itching or discharge, breakthrough bleeding or changes in your menstrual periods.

Contact your doctor if you experience any of the following side effects of Prempro:

  • Swelling or tenderness in the stomach.
  • Jaundice.
  • Memory problems, unusual behavior or confusion.
  • Unusual vaginal bleeding or pelvic pain.
  • Breast lumps.
  • Signs of a heart attack such as chest pain or pressure, pain spreading to your jaw or shoulder, nausea or sweating.
  • Signs of a stroke such as sudden numbness or weakness especially on one side of the body, sudden severe headache, slurred speech or problems with your vision or balance.
  • Signs of a blood clot such as sudden vision loss, stabbing chest pain, shortness of breath, coughing up blood or pain or warmth in one or both legs.
  • Signs of high levels of calcium in your blood such as nausea, vomiting, constipation, increased thirst or urination, muscle weakness, bone pain or lack of energy.
  • Signs of an allergic reaction such as hives, difficulty breathing or a swelling of your face, lips or throat.


Q: What else is Prempro called?

A: Prempro is also known as Premique. Premique is not a generic alternative but the same brand name medication with a different name internationally.

Q: What should I do if I miss a dose of Prempro?

A: If you miss a dose of this medication, take it as soon as you remember. If it is almost time for your next dose, then skip your missed dose.

A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

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