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Denavir cream is the brand name of peniclovir topical, an antiviral medication. It is usually prescribed to treat cold sores around the mouth that are caused by herpes simplex virus. Denavir cream has been approved for use in adults and children 12 years of age or older.

Denavir cream is not a cure for cold sores, and you may still experence cold sores in the future.

Use Denavir cream in the exact manner that your doctor has prescribed it to you. Avoid using this medication in smaller or larger doses that prescribed, or for a shorter or longer duration than your doctor has recommended.

Denavir cream is only approved for topical use, and should not enter your mouth. If you get the medication in your mouth or nose, rinse with water immediately. This medication should only be used to treat cold sores on the face and lips. 

Before applying the cream, wash your hands and the affected area. Be sure to wash your hands after application as well. 

Follow all of your doctor's instructions for application. Always read all information or handouts given to you by your healthcare providers.

If you see no difference in your symptoms, or your symptoms are getting worse, contact your doctor right away.

Store Denavir cream away from moisture and heat.


Do not apply Denavir cream on the inside of the nose or in or around the eyes.

You should avoid the use of Denavir cream if you're allergic to penciclovir.

Because penciclovir is only approved for use on the skin and is not absorbed into the body, using this medication is not expected to be dangerous if you are pregnant or breastfeeding. Talk to your doctor to find out about any possible risks.

Denavir cream isn't approved for use on children younger than 12 years old.

If you experience an allergic reaction while using Denavir cream, you should seek emergency medical attention. Signs of an allergic reaction may include, but are not limited to: 

  • Trouble breathing
  • Hives
  • Swelling of the lips, face, tongue, or throat

Call your doctor immediately if you experience and severe pain, rash, shin redness, or itching after applying the cream.

Side Effects

Denavir cream side effects may include, but are not limited to the following:

  • Headaches
  • Tingling or numbness at the application site
  • An altered sense of taste

This is not a full list of possible side efffects, and others may occur. Talk to your doctor about any possible side effects before using this medication for the first time.

It is not expected that Denavir cream will have an effect on other medications taken orally or injected, but there may be possible drug interactions. Talk to your doctor before taking this medication, and make sure that your doctor always has an up to date list of any medications, supplements, and vitamins that you are currently taking.


What are Denavir cream side effects?

Some common side effects of Denavir cream use are headahces, an altered sense of taste, and a numb or tingling feeling at the application site. This is not a full list of all possible side effects, and others may occur. Talk to your doctor about any other possible side effects that you may experience while taking the medication.

How should I store the medication?

Denavir cream should be stored away from moisture and heat, and you should tightly close the container between uses. Always keep Denavir cream, and any other medications, out of reach of children and pets.

Is it safe to take this medication while breastfeeding?

Since this medication is topical and is not absorbed into the body, it is not expected to pose any dangers to pregnant or breastfeeding women. Talk to your doctor before taking this medication for more information.

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January 9, 2023

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October 14, 2022

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A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

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