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What is Activella?

Activella is a combination medication containing estradiol and norethindrone which is used to treat menopause symptoms such as vaginal dryness and hot flashes. Estradiol replaces the hormone estrogen when the body is making less of it. Norethindrone helps to reduce the risk of cancer of the uterus which can be caused by using estrogen.

Always read the patient information and instructions carefully before using this medication.

• Take Activella orally with or without food and is typically taken once a day. Taking Activella with food or after a meal can help to prevent stomach upset.
• Your Activella dosage is based on your medical condition and your response to treatment. Do not change your dosage or the frequency you take this medication unless advised by a doctor.
• Activella is most effective when it is taken regularly. Try to take this medication at the same time each day. Tell your doctor if your condition does not improve or worsens.

Make sure to tell your doctor and pharmacist:

• If you have any drug allergies.
• Which other prescription and non-prescription medications you currently take.
• Your medical history especially of vaginal bleeding of an unknown cause, stroke, heart disease, liver disease, kidney disease, blood clotting disorders, high blood pressure, diabetes, high blood cholesterol, triglyceride levels, obesity, lupus, underactive thyroid, mineral imbalance, hypoparathyroidism, uterus problems, gallbladder disease, asthma, seizures, migraine headaches, porphyria and mental or mood disorders.
• Your personal or family history of breast lumps, cancer, blood clots or angioedema.
• If you will be or have just had surgery or if you will be confined to a bed or chair for an extended period of time, such as on a long flight. These conditions can increase your risk of getting blood clots and you may need to temporarily stop this medication or take special precautions.
• If you are breast feeding. Activella can reduce the quality and quantity of your breast milk.

Also be aware that:

• You should not smoke or use tobacco while using this medication. Combining estrogen and smoking can increase your risk of stroke, blood clots, heart attack and high blood pressure especially in women over 35.
• Activella can cause dark or blotchy areas on your skin and face which may be worsened by sunlight. You should limit your time in the sun and wear protective clothing and use sunscreen. Avoid tanning booths and sunlamps.
• Activella must not be used during pregnancy. Tell your doctor straight away if you think you might be pregnant.
• If you are nearsighted or wear contact lenses, you may develop vision problems. Talk to your eye doctor if this occurs.

Common Activella side effects may include but are not limited to:

• Stomach cramps, nausea, bloating or vomiting.
• Signs of fluid retention such as swelling or rapid weight gain.
• Headache or breast pain.
• Thinning scalp hair.
• Vaginal itching or discharge.
• Changes in your menstrual periods or breakthrough bleeding.

Contact your doctor if you experience any of the following side effects of Activella:

• Breast lumps.
• Pelvic pain or unusual vaginal bleeding.
• Jaundice.
• Swelling or tenderness in your stomach.
• Confusion, memory problems or unusual behavior.
• Signs of a heart attack such as nausea, sweating, chest pain or pressure or a pain spreading to your jaw or shoulder.
• Signs of a stroke such as slurred speech, vision problems, balance problems, sudden severe headache sudden numbness or weakness especially on one side of the body.
• Signs of a blood clot such as sudden vision loss, stabbing chest pain, shortness of breath, coughing up blood, pain or warmth in one or both legs.
• Signs of high levels of calcium in your blood such as nausea, vomiting, constipation, increased thirst or urination, muscle weakness, bone pain or a lack of energy.
• Signs of an allergic reaction such as hives, difficulty breathing or a swelling of your face, lips or throat.

Q: What else is Activella called?

A: Activella is also known as Activelle or Activelle LD. Activelle is not a generic alternative but the same brand name medication with a different name internationally.

Q: What should I do if I miss a dose of Activella?

A: If you miss a dose of this medication, take it as soon as you remember. If it is almost time for your next dose, then skip your missed dose