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What is Venlafaxine XR?

Venlafaxine Hydrochloride XR and the brand name Effexor XR are antidepressants used to treat major depressive disorder, anxiety and panic disorder. Venlafaxine XR is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant which affects chemicals in the brain which may be unbalanced. This medication may improve your mood, energy level and help to restore your interest in daily living.

Always read the patient information and instructions carefully before using this medication.

• Effexor XR is taken orally with food and is typically taken once a day either in the morning or evening.
• Swallow Venlafaxine XR whole without crushing. Do not crush, chew or dissolve this medication as this can release all of the drug at once increasing the chance of side effects. If scored, this medication can be split without crushing if advised by a doctor. If you have trouble swallowing these capsules whole, open the capsule and sprinkle onto a spoon of applesauce and swallow immediately without chewing. Drink a glass of water after each dose.
• Your Venlafaxine dosage is based on your medical condition and response to treatment. Do not change or increase your dosage unless advised by a doctor.
• Effexor XR is most effective when taken regularly. Try to take it at the same time each day. You should not stop taking this medication without speaking to a doctor as some conditions may worsen when this drug is stopped suddenly.
• It may take several weeks before you feel the benefit of this medication. Tell your doctor if your condition does not improve or worsens after this time.

Make sure to tell your doctor and pharmacist:

• If you have any drug allergies.
• Which other prescription and non-prescription medications you currently take.
• Your medical history especially of bleeding problems, high blood pressure, heart problems, high cholesterol, kidney disease, liver disease, seizure disorder or thyroid disease.
• Your personal and family history of glaucoma.
• If you are pregnant, planning pregnancy or breast feeding.

Also be aware that:

• Older adults may be more sensitive to the side effects of Effexor XR especially of dizziness and bleeding.
• Children may be more sensitive to the side effects of Effexor XR especially loss of appetite and weight loss.
• This medication may harm an unborn baby or have undesirable effects on a nursing infant. Discuss the risks of this medication with your doctor.

Common Effexor XR side effects may include but are not limited to:

• Dizziness, drowsiness or sleep problems.
• Anxiety or nervousness.
• Vision changes.
• Nausea, vomiting or diarrhea.
• Changes in appetite or weight.
• Dry mouth or yawning.
• Increased sweating.
• Decreased sex drive, impotence, abnormal ejaculation or difficulty in having an orgasm.

Seek immediate medical help if you have symptoms of serotonin syndrome such as agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of co-ordination, nausea, vomiting or diarrhea.

Contact your doctor if you experience any of the following Effexor XR side effects:

• Mood or behavior changes such as anxiety, panic attacks, trouble sleeping, impulsiveness, irritation, agitation, hostility, aggressiveness, restlessness, hyperactivity, increased depression or suicidal thoughts.
• Vision changes such as blurred vision, tunnel vision, eye pain or seeing halos around lights.
• Easy bruising or bleeding such as nosebleeds, blood in your urine or stools or coughing up blood.
• Coughing, chest tightness or breathing problems.
• Seizures.
• Signs of a low sodium level such as headaches, confusion, slurred speech, weakness, vomiting, loss of co-ordination or feeling unsteady.
• Signs of a nervous system reaction such as stiff muscles, high fever, sweating, confusion, uneven or fast heartbeats, tremors or the feeling like you might pass out
• Signs of an allergic reaction such as rashes, hives, breathing difficulty or swelling of the face, lips, tongue or throat.

Q: How long does it take Venlafaxine XR to work?

A: It may take several weeks before you feel the benefit of this medication. Tell your doctor if your condition does not improve or worsens after this time.

Q: What should I do if I miss a dose of Venlafaxine XR?

A: Take the missed dose as soon as you remember. If it is almost time for your next dose, then skip your missed dose. Do not take two doses at once.