Xifaxan (rifaximin) is an antibiotic prescribed for conditions such as traveler’s diarrhea, irritable bowel syndrome with diarrhea (IBS-D), and hepatic encephalopathy. Unlike many antibiotics, it stays in the digestive tract rather than entering the bloodstream, which helps target gut bacteria directly where they’re needed.

How does Xifaxan work?

By acting locally in the intestines, Xifaxan reduces the overgrowth of harmful bacteria. This helps restore balance in the gut, eases diarrhea, and prevents recurrent complications linked to certain liver disorders.

Always read the patient information and instructions carefully before using this medication.

• Xifaxan can be taken with or without food.
• Your doctor will determine your Xifaxan dosage based on the reason it is being prescribed, your medical condition, and your response to treatment.
• As an IBS treatment, Xifaxan is typically taken 3 times daily for 14 days.
• As a traveler's diarrhea treatment, Xifaxan is usually taken every 8 hours. You should complete the full prescribed amount of antibiotics even when your symptoms have disappeared.
• To prevent hepatic encephalopathy, this medication is normally taken twice daily.

Cautions

Make sure to tell your doctor and pharmacist:

• If you have any drug allergies.
• Any other prescription and non-prescription medications you are taking.
• Your medical history.
• If you are breastfeeding.

Also, be aware that:

• During pregnancy, Xifaxan should only be taken when clearly needed.
• Live bacterial vaccines, such as the typhoid vaccine, may be less effective when taken with Xifaxan. Therefore, you should not have any immunizations or vaccinations while taking it.

Side Effects

Common Xifaxan side effects may include, but are not limited to:

• Swelling in your hands or feet.
• Headaches, tiredness, or dizziness.
• Nausea. 
• Abnormal liver function tests.

Contact your doctor if you experience any of the following side effects of Xifaxan:

• Severe stomach pain.
• Bloody or watery diarrhea. Tell your doctor even if this happens months after you finish taking Xifaxan.
• Fluid buildup around the stomach, such as rapid weight gain, stomach pain, bloating, or breathing problems when lying down.

Canada Drug Warehouse offers both brand-name Xifaxan and its generic version, called rifaximin, at competitive prices. Patients who choose the generic option can save substantially while receiving the same active ingredient.

Price Table – Xifaxan and Generic Rifaximin (550 mg)

Canada vs U.S. Prices

Xifaxan is known to be very costly in the United States. Patients often turn to Canadian pharmacies because the price gap is so significant.

Comparison Overview

In the U.S., brand Xifaxan 550 mg can cost $25–$30 per pill without insurance. At Canada Drug Warehouse, the same brand is available for about $13 per pill. Choosing generic rifaximin reduces the cost even further to around $1.72 per pill. This means U.S. patients could save up to 90% by ordering through a Canadian pharmacy.

Purchasing Xifaxan online from Canada Drug Warehouse is a secure and straightforward process.

Steps to Order

1. Visit Canada Drug Warehouse and enter the medication name in the search bar.
2. Select your dosage and quantity, then click “Add to Cart” and proceed to checkout.
3. Log in if you already have an account, or create a new one. Prefer to order by phone? Call 1-877-204-1506.
4. Upload your prescription online or ask us to contact your doctor or pharmacy on your behalf.
5. Review your details and complete your order.
6. Your medication will be shipped directly to your door.

Why choose a Canadian pharmacy for Xifaxan?

Ordering Xifaxan or its generic equivalent from a Canadian pharmacy combines affordability with safety. All medications are dispensed from licensed facilities and shipped in discreet packaging to ensure patient privacy and product integrity.

Does insurance cover Xifaxan?

Many U.S. insurance providers either do not cover Xifaxan or require high copays. Ordering through Canada Drug Warehouse often results in lower out-of-pocket costs, even without insurance.

What’s the difference between brand and generic rifaximin?

Both contain the same active ingredient and work in the same way. The main difference is cost—generic rifaximin is far more affordable.

Are bulk savings available for Xifaxan?

Yes. Ordering Xifaxan (rifaximin) in larger quantities, such as a 200-tablet supply, can significantly reduce the per-pill cost to around $1.72, offering meaningful long-term savings for ongoing treatment.

How should Xifaxan be taken?

Xifaxan should always be taken exactly as prescribed by your healthcare provider, since the dosage depends on the condition being treated. Typical directions are:

• Traveler’s diarrhea: 200 mg every 8 hours for 3 days.
• Irritable bowel syndrome with diarrhea (IBS-D): 550 mg three times daily for 14 days.
• Hepatic encephalopathy: 550 mg twice daily, usually for long-term use to reduce recurrence.

Take each dose with or without food, swallowing the tablet whole with a glass of water. Do not stop the medication early, even if you feel better, unless directed by your doctor.

What conditions does Xifaxan treat?

Xifaxan is commonly prescribed for:

• Traveler’s diarrhea caused by non-invasive E. coli
• IBS-D (irritable bowel syndrome with diarrhea)
• Reducing the risk of hepatic encephalopathy recurrence

What are the common side effects of Xifaxan?

Common Xifaxan side effects may include mild nausea, gas, stomach pain, or headache. These effects are usually temporary, but patients should contact their healthcare provider if symptoms persist or worsen.

Can I safely switch from brand-name Xifaxan to generic rifaximin?

Yes. Generic rifaximin provides the same active ingredient, dosage strength, and therapeutic benefits as brand-name Xifaxan. Patients should always consult their doctor or pharmacist before making the switch to ensure proper continuity of care.

How quickly does Xifaxan start working?

Some patients experience relief within a few days, although the timing varies depending on the condition and the prescribed dosage.

Is Xifaxan an IBS medication?

Yes, Xifaxan is prescribed to treat irritable bowel syndrome (IBS) as well as traveler's diarrhea and hepatic encephalopathy.

How much does Xifaxan cost?

The price of Xifaxan is based on whether you buy the brand-name or the generic alternative Rifaximin. You can get Xifaxan 550mg or Rifaximin in 550mg or 400mg. You don’t need a Xifaxan coupon to get our great prices.

What should I do if I miss a dose of Xifaxan?

If you forget to take a dose of Xifaxan, take it as soon as you remember. If it is almost time for your next dose, then skip the missed dose. Do not take two doses at one time.