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What is Desvenlafaxine?

Desvenlafaxine and the brand name Pristiq are antidepressants which affect brain chemicals which may be unbalanced in people with depression. Pristiq is an SNRI (selective serotonin and norepinephrine reuptake inhibitors) used to treat major depressive disorder.

Always read the patient information and instructions carefully before using this medication.

• Desvenlafaxine should be taken orally and can be taken with or without food. This medication is typically taken once daily.
• Swallow desvenlafaxine whole without crushing, chewing or dissolving it as this may release all of the drug at once increasing the risk of side effects. Do not split these tablets unless they are scored and you are advised to by a doctor.
• Do not change or increase your desvenlafaxine dosage unless advised by a doctor. Using more medication than prescribed will not improve your condition any faster but may increase the chance of side effects.
• Pristiq ER should be taken regularly. Try to take it at the same time each day. It is important to continue to take this medication even if you feel well. Some conditions may worsen when this drug is stopped. It may take several weeks before you feel the full benefit of this medication.
• When switching from another antidepressant, your doctor may want to slowly reduce the dose of your previous medication to prevent withdrawal symptoms.
• Avoid alcohol while taking this medication.

Make sure to tell your doctor and pharmacist:

• If you have any drug allergies.
• Which other prescription and non-prescription medications you currently take.
• Your medical history, especially of bleeding problems, high blood pressure, heart problems, stroke, high cholesterol, kidney disease, liver disease, seizure disorder or low sodium in the blood.
• Your personal and family history of psychiatric disorders, suicide attempts of glaucoma.
• If you are pregnant, planning pregnancy or breast feeding.

Also be aware that:

• Pristiq ER may make you dizzy, drowsy or blur your vision. Do not drive, operate machinery or do any other activity requiring alertness until it can be done safely.
• Older adults and children may be more sensitive to the side effects of Pristiq ER.
• This medication may harm an unborn baby or have undesirable effects on a nursing infant.

Common Desvenlafaxine side effects may include but are not limited to:

• Dizziness or drowsiness.
• Anxiety.
• Increased sweating.
• Nausea, constipation or decreased appetite.
• Sleeping problems.
• Decreased sex drive, impotence or difficulty having an orgasm.

Get immediate medical attention if you have signs of serotonin syndrome such as agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting or diarrhea.

Contact your doctor if you experience any of the following Desvenlafaxine side effects:

• Any new or worsening symptoms such as mood changes, anxiety, panic attacks, sleeping problems, impulsiveness, irritation, agitation, hostility, aggressiveness, restlessness, hyperactivity, increased depression, or suicidal thoughts or thoughts about hurting yourself.
• Seizures.
• Easy bruising or bleeding such as nosebleeds, coughing up blood, bleeding gums or blood in your urine or stools.
• Vision changes such as blurred vision, eye pain, swelling or seeing halos around lights.
• Coughing, chest discomfort or breathing problems.
• Signs of a low level of sodium in the body such as headaches, confusion, severe weakness, memory problems, hallucinations or feeling unsteady.
• Signs of an allergic reaction such as skin rash, hives, breathing difficulties or swelling of the face, tongue or throat.

Q: How long does it take desvenlafaxine to work?

A: It may take several weeks before you feel the full benefit of this medication. Continue to take it regularly.

Q: Can I take alcohol with desvenlafaxine?

A: You should avoid alcohol while taking this medication.